Rational design of new thiazolo-thiazole dyes as input energy units in molecular dyads.

Direct arylation as a versatile tool towards thiazolo[5,4-d]thiazole-based semiconducting materials.

A series of thiazolo[5,4-d]thiazole-based small molecule organic optoelectronic materials is synthesized via a straightforward microwave-activated Pd-catalyzed C-H arylation protocol. The procedure allows us to obtain extended 2,5-dithienylthiazolo[5,4-d]thiazole chromophores with tailor-made energy levels and absorption patterns, depending on the introduced (het)aryl moieties and the molecular...

New Liquid Crystalline Polyurethane Elastomers Containing Thiazolo [5,4d] Thiazole Moiety: Synthesis and Properties

Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...

Diastereoisomeric dinuclear ruthenium complexes of 2,5-di(2-pyridyl)thiazolo[5,4-d]thiazole.

The first metal complexes of 2,5-di(2-pyridyl)thiazolo[5,4-d]thiazole (5) are described. X-Ray crystal structures are reported for the free ligand 5, a dinuclear copper complex 6 and the two diastereoisomers, 7meso and 7rac, of the dinuclear bis(2,2'-bipyridine)ruthenium complex. The two diastereoisomers of 7 and the 4,4'-dimethyl-2,2'-bipyridine analogue 8 are readily separated by cation excha...

Design, Synthesis and Biological Evaluation of New Imidazo[2,1-b]Thiazole Derivatives as Selective COX-2 Inhibitors

A new series of imidazo[2,1-b]thiazole analogs containing a methyl sulfonyl COX-2 pharmacophore was synthesized and evaluated for their COX-2 inhibitory activity. According to in-vitro COX-1/COX-2 inhibition data, all compounds (6a-g) were selective inhibitors of COX-2 isoenzyme with IC50 values in the highly potent 0.08-0.16 mM range. These results indicated that both potency and selectivity o...